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K9 Advantix II for Dogs 4-Month Supply

Regularly: $67.99
Today's savings: 28%

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In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.

Over 55lb


In Stock. Usually Ships within 24 hours.

Shipping weight = 0.10 lb.


Product Summary:

K9 Advantix II Dog: 4-Month Supply

K9 Advantix II delivers pest protection through topical action. It protects against fleas (flea eggs and larvae), ticks, mosquitoes, biting flies, and lice. It combines imidacloprid and permethrin with insect growth regulator pyriproxyfen, which interferes with the hormone signaling of molting insects so that fleas in immature stages are unable to molt. K9 Advantix II is for monthly use on puppie as young as 7 weeks old and dogs. Do not use on cats.

  • Repels and kills ticks, fleas, and mosquitoes
  • Repels biting flies
  • Kills lice
  • Kills all life stages of fleas
  • Prevents development of fleas, flea eggs, and larvae
  • Kills fleas within 12 hours of initial application
  • Kills reinfesting fleas within 2 hours
  • Protects against ticks that may transmit organisms that can cause Lyme disease, Rocky Mountain spotted fever, Ehrlichiosis, and Anaplasmosis
  • Waterproof: continues to work after a bath or weekly swimming (for optimal results, use a non-detergent shampoo)
  • One application lasts for a month
  • Can be used on puppies as young as 7 weeks old
  • Easy-to-follow application instructions on the back of every package
Item Specifications:

4-10 lb.: Green
11-20 lb.: Teal
21-55 lb.: Red
Over 55 lb.: Blue

Includes four applicators

Apply the entire contents of the tube evenly to two to three spots on the top of the back from the shoulder to the base of the tail. Monthly application.

Length of Effectiveness:
Under normal conditions, the product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days. After flea control is attained, return to a monthly retreatment schedule.

8.80% Imidacloprid
44.00% Permethrin
0.44% Pyriproxyfen
46.76% other ingredients
Active ingredients work synergistically. The combination of imidacloprid with permethrin exerts a unique synergistic effect on the arthropod nervous system that is greater than either ingredient alone. Each compound acts on a different receptor area of the nerve cell:

  • Imidacloprid: (nicotinic receptors) irreversibly opens nicotinic receptors on postsynaptic neurons, resulting in constant neuromuscular stimulation, spastic paralysis, and death
  • Permethrin: (sodium channels) causes prolonged sodium ion exchange across neuronal membranes, resulting in constant nerve discharge followed by spastic paralysis and death
  • When both ingredients are combined, the neurotoxic stimulation is greater than that seen with either ingredient alone
Downloadable Resources
Comparison ChartK9 Advantix II vs Frontline Plus
MSDSK9 Advantix II
Style Item Number Model Number UPC
4-10lb 405588 001 5420348 724089203489
11-20lb 405588 002 5420372 724089203724
21-55lb 405588 003 5420399 724089203991
Over 55lb 405588 004 5420410 724089204103

Product Reviews by Customers

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Browse 1 question Browse 1 question and 26 answers
Why did you choose this?
KV Supply Store
The only protection we've ever used...23 years and counting.
ROBERT C on May 9, 2019
Because it works
Discover J on Jan 5, 2019
The only protection we've ever used...23 years and counting.
ROBERT C on May 9, 2019
Works very good.
DEBORAH W on Mar 24, 2019
Because it works
Discover J on Jan 5, 2019
always used this product. works well on my dog
ANGELO P on Dec 6, 2018
works great for our Labradoodle
Robin L H on Sep 22, 2018
easy to apply and seems to work good using this for the past 4 years
DIANA O on Jun 13, 2018
It works.
GISELA H on May 26, 2018
because it works!
MICHELLE H on May 20, 2018
It has kept my fur babies flea & tick free, repels mosquitoes, priced right with free shipping.
Karen B on May 14, 2018
I had pretty good results with this product.
Rhonda W on Apr 17, 2018
It works!
Violette W on Mar 14, 2018
I have used it before and it works.
M A on Mar 4, 2018
it works
Janice G on Nov 3, 2017
It works
ROBERT C on Oct 22, 2017
protection to our golden rec.
DIANA O on Oct 15, 2017
I felt that this was a better deal than Chewy
ELAINE J on Oct 5, 2017
vet recommended
M S on Sep 30, 2017
Because it works. Been using it for years. Easy to use, quite effective.
CAROL B on Sep 24, 2017
Recommended by vet.
MARION S on Sep 22, 2017
best ever
Dee G on Sep 6, 2017
cause it WORKS on my Dogs that's why
ANGELO P on Aug 23, 2017
It works great on my dogs.
Robin L H on Aug 12, 2017
I believe it's safer than giving internal medications. It works better than other products I've tried, and seems to be cost effective comparatively.
Mary S on Aug 11, 2017
Have always used it in the past with good results
PAULA N on Aug 7, 2017
this product works very well
MICHELLE H on Aug 5, 2017
Works great
RANDI P on Jul 21, 2017
Works very good.
DEBORAH W on Mar 24, 2019
always used this product. works well on my dog
ANGELO P on Dec 6, 2018