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K9 Advantix II for Dogs 6-Month Supply

Regularly: $92.99
Today's savings: 27%

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In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.



In Stock. Usually Ships within 24 hours.

Over 55lb


In Stock. Usually Ships within 24 hours.

Shipping weight = 0.10 lb.


Product Summary:

K9 Advantix II Dog: 6-Month Supply

K9 Advantix II delivers pest protection through topical action. It protects against fleas (flea eggs and larvae), ticks, mosquitoes, biting flies, and lice. It combines imidacloprid and permethrin with insect growth regulator pyriproxyfen, which interferes with the hormone signaling of molting insects so that fleas in immature stages are unable to molt. K9 Advantix II is for monthly use on puppie as young as 7 weeks old and dogs. Do not use on cats.

  • Repels and kills ticks, fleas, and mosquitoes
  • Repels biting flies
  • Kills lice
  • Kills all life stages of fleas
  • Prevents development of fleas, flea eggs, and larvae
  • Kills fleas within 12 hours of initial application
  • Kills reinfesting fleas within 2 hours
  • Protects against ticks that may transmit organisms that can cause Lyme disease, Rocky Mountain spotted fever, Ehrlichiosis, and Anaplasmosis
  • Waterproof: continues to work after a bath or weekly swimming (for optimal results, use a non-detergent shampoo)
  • One application lasts for a month
  • Can be used on puppies as young as 7 weeks old
  • Easy-to-follow application instructions on the back of every package
Item Specifications:

4-10 lb.: Green
11-20 lb.: Teal
21-55 lb.: Red
Over 55 lb.: Blue

Includes six applicators

Apply the entire contents of the tube evenly to two to three spots on the top of the back from the shoulder to the base of the tail. Monthly application.

Length of Effectiveness:
Under normal conditions, the product is effective for a month. However, in cases of severe flea infestation, retreatment may be necessary earlier than four weeks. Do not retreat more often than once every seven (7) days. After flea control is attained, return to a monthly retreatment schedule.

8.80% Imidacloprid
44.00% Permethrin
0.44% Pyriproxyfen
46.76% other ingredients
Active ingredients work synergistically. The combination of imidacloprid with permethrin exerts a unique synergistic effect on the arthropod nervous system that is greater than either ingredient alone. Each compound acts on a different receptor area of the nerve cell:

  • Imidacloprid: (nicotinic receptors) irreversibly opens nicotinic receptors on postsynaptic neurons, resulting in constant neuromuscular stimulation, spastic paralysis, and death
  • Permethrin: (sodium channels) causes prolonged sodium ion exchange across neuronal membranes, resulting in constant nerve discharge followed by spastic paralysis and death
  • When both ingredients are combined, the neurotoxic stimulation is greater than that seen with either ingredient alone
Downloadable Resources
Comparison ChartK9 Advantix II vs Frontline Plus
MSDSK9 Advantix II
Style Item Number Model Number UPC
4-10lb 405589 001 5420364 724089203649
11-20lb 405589 002 5420380 724089203809
21-55lb 405589 003 5420402 724089204028
Over 55lb 405589 004 5420429 724089204295

Product Reviews by Customers

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Browse 3 questions Browse 3 questions and 53 answers
Why did you choose this?
KV Supply Store
works well form my dogs for many years now
JENNIFER W on Aug 29, 2019
Good value for this product
GREGORY B on Jun 2, 2019
works well form my dogs for many years now
JENNIFER W on Aug 29, 2019
Have been using product for 9 years and it has proven to be the best protection for my chihuahua. Have looked at other products but would not use anything else.
WILLIAM B on Jun 30, 2019
Good value for this product
GREGORY B on Jun 2, 2019
Have used before and it's great.
Linda L on May 9, 2019
Mosquito control
Mary R on Apr 21, 2019
We have 6 dogs and we are extremely satisfied with the outcome of this product for our dogs. We have been using this same product for the past 16 years.
Robin L H on Mar 30, 2019
I have tried other products with poor results. This is the only product that does not cause allergic reactions in my dog. Plus, it really works. No live fleas or ticks on my dog.
WILLIAM R on Mar 25, 2019
Works very good.
DEBORAH W on Mar 24, 2019
Love how this product repels mosquitos. I don't use heartworm meds.
DIANE J on Mar 15, 2019
Because it works!
DANA W on Mar 13, 2019
Works on our current dog and on two previous dogs.
LOUISE O on Mar 6, 2019
It has been a staple for our dogs
JENNIFER W on Feb 14, 2019
to protect my dog from fleas and ticks
debbie e on Feb 13, 2019
It's worked for years on my dogs.
J H on Dec 31, 2018
This has provides good results on all three dogs Pit-Catahoula and wienie mix
JACK W on Oct 23, 2018
Works GREAT on my Shepherds...have used it for years
Debra B on Sep 23, 2018
works the best for our Labs
Robin L H on Sep 22, 2018
It works!!!!!
JUDY S on Aug 31, 2018
For flea and tick control.
SHARON B on Aug 21, 2018
Because it repels as well as kills fleas, ticks and flies
SUE ANN T on Aug 18, 2018
I like the fact that it kllls ticks, mosquitos and flies
Carol M on Aug 9, 2018
Does kill ticks where the sentinel flea and heartworm does not
francis c on Aug 1, 2018
My dog has been on this from the time we got him and we have a lot of Tics in the area. this product works the best for us.
MARCIA B on Jul 21, 2018
It works
DARLENE M on Jul 14, 2018
this item is recommended by my veterinarian
KATHRYN R on Jul 8, 2018
Easily keeps the bad bugs off and out of the house!<br />Been using it for years and no issues.
Chris H on Jul 3, 2018
Always works.
DEBORAH W on Jun 26, 2018
Because it always works
SUZETTA C on Jun 22, 2018
I have been using this product for years since it first came out.<br />I live in a very wooded area and it can be pretty wet causing mosquito blooms. <br />I have never seen fleas or ticks on my dogs, and the mosquitos are never landing on them but are attacking me! Hi Highly reccomend.
HAROLD R on May 21, 2018
it works great
Rosa S on May 18, 2018
JUDY S on May 7, 2018
I have three dogs, two weigh forty pounds and one weighs over fifty-five. I have found this flea product to be the most economical and most efficient for me.
Eizabeth S on May 5, 2018
Been using it for years.
T D on Apr 27, 2018
Have been using Advantix for years and it works!
Lia S on Apr 27, 2018
Used by Vet
R R on Apr 23, 2018
Works just fine. Have used it for several years.
JEAN B on Apr 17, 2018
great price!
PHYLLIS W on Apr 13, 2018
We've used K9 advantix for years with our dogs
HENRY T on Apr 9, 2018
It work good.
PENNY C on Apr 7, 2018
I have used this product for years on my dogs. it works great
Juanita F on Apr 6, 2018
I have found this product works and you don't need a prescrition to get it.
DIANE W on Mar 31, 2018
works great.
DEBORAH W on Mar 29, 2018
Because they work
EUGENE C on Mar 22, 2018
It protect against mosquito bites
BETTY L on Mar 21, 2018
Think it is the best, all I have ever used on all my Dogs.
DONALD B on Mar 20, 2018
Works well and no side effects for my dog
JOSEPH S on Mar 16, 2018
Good product and discount.
Ellen G on Mar 15, 2018
I have two small dogs which need this medications they live outdoors.
Eizabeth S on Mar 13, 2018
works the best for our 7 dogs.
Robin L H on Mar 10, 2018
This is reorder. It works well and is at a great price!
Laura D on Mar 5, 2018
Have been using product for 9 years and it has proven to be the best protection for my chihuahua. Have looked at other products but would not use anything else.
WILLIAM B on Jun 30, 2019
Have used before and it's great.
Linda L on May 9, 2019
Do you still need to use Heartworm meds since this repels mosquitos also?
A shopper on Feb 5, 2018
BEST ANSWER: Yes, it is recommended to still use heartworm preventative.
can this be used on a nursing dog?
A shopper on Jul 23, 2017
BEST ANSWER: Hi there,

Per the manufacturer of the product, you would want to consult with your veterinarian before using on a nursing mother.