Rimadyl Chewable Tablets

Prescription Required
From $319.99


Sometimes, manufacturers require that products be advertised only at their suggested prices. When we choose to sell these items for less, we display the sale price only in the cart. To see the price, click Add to Cart.


Select your product options above to view the stock and delivery information.

All medications are filled by Pet's Choice Pharmacy. More information. Can only be shipped in the United States.
Save item

Product Summary:

Rimadyl® Chewable Tablets


Rimadyl is indicated for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries in dogs. It is a non-steroidal anti-inflammatory drug.

Item Specifications:


For Use:









30 Tablets
60 Tablets
180 Tablets



Pfizer Animal Health

Use as Directed by your Veterinarian


Rimadyl (carprofen) is a non-steroidal anti-inflammatory drug (NSAID) of the propionic acid class that includes ibuprofen naproxen and ketoprofen. Carprofen is the nonproprietary designation for a substituted carbazole 6-chloro-α-methyl-9H-carbazole-2-acetic acid. The empirical formula is C15H12ClNO2 and the molecular weight 273.72. The chemical structure of carprofen is:

Carprofen is a white crystalline compound. It is freely soluble in ethanol but practically insoluble in water at 25°C.

Carprofen is a non-narcotic non-steroidal anti-inflammatory agent with characteristic analgesic and antipyretic activity approximately equipotent to indomethacin in animal models.1
The mechanism of action of carprofen like that of other NSAIDs is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals.2 The constitutive cyclooxygenase COX-1 synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase COX-2 generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity. The specificity of a particular NSAID for COX-2 versus COX-1 may vary from species to species.3 In an in vitro study using canine cell cultures carprofen demonstrated selective inhibition of COX-2 versus COX-1.4 Clinical relevance of these data has not been shown. Carprofen has also been shown to inhibit the release of several prostaglandins in two inflammatory cell systems: rat polymorphonuclear leukocytes (PMN) and human rheumatoid synovial cells indicating inhibition of acute (PMN system) and chronic (synovial cell system) inflammatory reactions.1
Several studies have demonstrated that carprofen has modulatory effects on both humoral and cellular immune responses.5-9 Data also indicate that carprofen inhibits the production of osteoclast-activating factor (OAF) PGE1 and PGE2 by its inhibitory effect in prostaglandin biosynthesis.1
Based upon comparison with data obtained from intravenous administration carprofen is rapidly and nearly completely absorbed (more than 90% bioavailable) when administered orally.10 Peak blood plasma concentrations are achieved in 1-3 hours after oral administration of 1 5 and 25 mg/kg to dogs. The mean terminal half-life of carprofen is approximately 8 hours (range 4.5-9.8 hours) after single oral doses varying from 1-35 mg/kg of body weight. After a 100 mg single intravenous bolus dose the mean elimination half-life was approximately 11.7 hours in the dog. Rimadyl is more than 99% bound to plasma protein and exhibits a very small volume of distribution.
Carprofen is eliminated in the dog primarily by biotransformation in the liver followed by rapid excretion of the resulting metabolites (the ester glucuronide of carprofen and the ether glucuronides of 2 phenolic metabolites 7-hydroxy carprofen and 8-hydroxy carprofen) in the feces (70-80%) and urine (10-20%). Some enterohepatic circulation of the drug is observed.

A controlled palatability study was conducted which demonstrated that Rimadyl chewable tablets were readily accepted and consumed on first offering by a majority of dogs.

Confirmation of the effectiveness of Rimadyl for the relief of pain and inflammation associated with osteoarthritis and for the control of postoperative pain associated with soft tissue and orthopedic surgeries was demonstrated in 5 placebo-controlled masked studies examining the anti-inflammatory and analgesic effectiveness of Rimadyl caplets in various breeds of dogs.
Separate placebo-controlled masked multicenter field studies confirmed the anti-inflammatory and analgesic effectiveness of Rimadyl caplets when dosed at 2 mg/lb once daily or when divided and administered at 1 mg/lb twice daily. In these 2 field studies dogs diagnosed with osteoarthritis showed statistically significant overall improvement based on lameness evaluations by the veterinarian and owner observations when administered Rimadyl at labeled doses.
Separate placebo-controlled masked multicenter field studies confirmed the effectiveness of Rimadyl caplets for the control of postoperative pain when dosed at 2 mg/lb once daily in various breeds of dogs. In these studies dogs presented for ovariohysterectomy cruciate repair and aural surgeries were administered Rimadyl preoperatively and for a maximum of 3 days (soft tissue) or 4 days (orthopedic) postoperatively. In general dogs administered Rimadyl showed statistically significant reduction in pain scores compared to controls.

Laboratory studies in unanesthetized dogs and clinical field trials have demonstrated that Rimadyl is well tolerated in dogs after oral administration.
In target animal safety studies Rimadyl was administered orally to healthy Beagle dogs at 1 3 and 5 mg/lb twice daily (1 3 and 5 times the recommended total daily dose) for 42 consecutive days with no significant adverse reactions. Serum albumin for a single female dog receiving 5 mg/lb twice daily decreased to 2.1 g/dL after 2 weeks of treatment returned to the pre-treatment value (2.6 g/dL) after 4 weeks of treatment and was 2.3 g/dL at the final 6-week evaluation. Over the 6-week treatment period black or bloody stools were observed in 1 dog (1 incident) treated with 1 mg/lb twice daily and in 1 dog (2 incidents) treated with 3 mg/lb twice daily. Redness of the colonic mucosa was observed in 1 male that received 3 mg/lb twice daily.
Two of 8 dogs receiving 10 mg/lb orally twice daily (10 times the recommended total daily dose) for 14 days exhibited hypoalbuminemia. The mean albumin level in the dogs receiving this dose was lower (2.38 g/dL) than each of 2 placebo control groups (2.88 and 2.93 g/dL respectively). Three incidents of black or bloody stool were observed in 1 dog. Five of 8 dogs exhibited reddened areas of duodenal mucosa on gross pathologic examination. Histologic exam of these areas revealed no evidence of ulceration but did show minimal congestion of the lamina propria in 2 of the 5 dogs.
In separate safety studies lasting 13 and 52 weeks respectively dogs were administered orally up to 11.4 mg/lb/day (5.7 times the recommended total daily dose of 2 mg/lb) of carprofen. In both studies the drug was well tolerated clinically by all of the animals. No gross or histologic changes were seen in any of the treated animals. In both studies dogs receiving the highest doses had average increases in serum L-alanine aminotransferase (ALT) of approximately 20 IU.
In the 52-week study minor dermatologic changes occurred in dogs in each of the treatment groups but not in the control dogs. The changes were described as slight redness or rash and were diagnosed as non-specific dermatitis. The possibility exists that these mild lesions were treatment related but no dose relationship was observed.
Clinical field studies were conducted with 549 dogs of different breeds at the recommended doses for 14 days (297 dogs were included in a study evaluating 1 mg/lb twice daily and 252 dogs were included in a separate study evaluating 2 mg/lb once daily). In both studies the drug was clinically well tolerated and the incidence of clinical adverse reactions for Rimadyl-treated animals was no higher than placebo-treated animals (placebo contained inactive ingredients found in Rimadyl). For animals receiving 1 mg/lb twice daily the mean post-treatment serum ALT values were 11 IU greater and 9 IU less than pre-treatment values for dogs receiving Rimadyl and placebo respectively. Differences were not statistically significant. For animals receiving 2 mg/lb once daily the mean post-treatment serum ALT values were 4.5 IU greater and 0.9 IU less than pre-treatment values for dogs receiving Rimadyl and placebo respectively. In the latter study 3 Rimadyl-treated dogs developed a 3-fold or greater increase in (ALT) and/or (AST) during the course of therapy. One placebo-treated dog had a greater than 2-fold increase in ALT. None of these animals showed clinical signs associated with laboratory value changes. Changes in the clinical laboratory values (hematology and clinical chemistry) were not considered clinically significant. The 1 mg/lb twice daily course of therapy was repeated as needed at 2-week intervals in 244 dogs some for as long as 5 years.
Clinical field studies were conducted in 297 dogs of different breeds undergoing orthopedic or soft tissue surgery. Dogs were administered 2 mg/lb of Rimadyl two hours prior to surgery then once daily as needed for 2 days (soft tissue surgery) or 3 days (orthopedic surgery). Rimadyl was well tolerated when used in conjunction with a variety of anesthetic-related drugs. The type and severity of abnormal health observation in Rimadyl- and placebo-treated animals were approximately equal and few in number (see Adverse Reactions). The most frequent abnormal health observation was vomiting and was observed at approximately the same frequency in Rimadyl- and placebo-treated animals. Changes in clinicopathologic indices of hematopoetic renal hepatic and clotting function were not clinically significant. The mean post-treatment serum ALT values were 7.3 IU and 2.5 IU less than pre-treatment values for dogs receiving Rimadyl and placebo respectively. The mean post-treatment AST values were 3.1 IU less for dogs receiving Rimadyl and 0.2 IU greater for dogs receiving placebo.

Rimadyl should not be used in dogs exhibiting previous hypersensitivity to carprofen.

As a class cyclooxygenase inhibitory NSAIDs may be associated with gastrointestinal and renal toxicity. Effects may result from decreased prostaglandin production and inhibition of the enzyme cyclooxygenase which is responsible for the formation of prostaglandins from arachidonic acid.11-14 When NSAIDs inhibit prostaglandins that cause inflammation they may also inhibit those prostaglandins which maintain normal homeostatic function. These anti-prostaglandin effects may result in clinically significant disease in patients with underlying or pre-existing disease more often than in healthy patients.12 14 NSAID therapy could unmask occult disease which has previously been undiagnosed due to the absence of apparent clinical signs. Patients with underlying renal disease for example may experience exacerbation or decompensation of their renal disease while on NSAID therapy.11-14 The use of parenteral fluids during surgery should be considered to reduce the potential risk of renal complications when using NSAIDs perioperatively.
Carprofen is an NSAID and as with others in that class adverse reactions may occur with its use. The most frequently reported effects have been gastrointestinal signs. Events involving suspected renal hematologic neurologic dermatologic and hepatic effects have also been reported. Patients at greatest risk for renal toxicity are those that are dehydrated on concomitant diuretic therapy or those with renal cardiovascular and/or hepatic dysfunction. Concurrent administration of potentially nephrotoxic drugs should be approached cautiously with appropriate monitoring. Since many NSAIDs possess the potential to induce gastrointestinal ulceration concomitant use of Rimadyl with other anti-inflammatory drugs such as corticosteroids and NSAIDs should be avoided or very closely monitored. Sensitivity to drug-associated adverse reactions varies with the individual patient. For example Rimadyl treatment was not associated with renal toxicity or gastrointestinal ulceration in well-controlled safety studies of up to ten times the dose in dogs.
Rimadyl is not recommended for use in dogs with bleeding disorders (e.g. Von Willebrand’s disease) as safety has not been established in dogs with these disorders. The safe use of Rimadyl in animals less than 6 weeks of age pregnant dogs dogs used for breeding purposes or in lactating bitches has not been established. Studies to determine the activity of Rimadyl when administered concomitantly with other protein-bound or similarly metabolized drugs have not been conducted. Drug compatibility should be monitored closely in patients requiring additional therapy. Such drugs commonly used include cardiac anticonvulsant and behavioral medications. It has been suggested that treatment with carprofen may reduce the level of inhalant anesthetics needed.15
If additional pain medication is warranted after administration of the total daily dose of Rimadyl alternative analgesia should be considered. The use of another NSAID is not recommended.
Due to the palatable nature of Rimadyl chewable tablets store out of reach of dogs in a secured location. Severe adverse reactions may occur if large quantities of tablets are ingested. If you suspect your dog has consumed Rimadyl chewable tablets above the labeled dose please call your veterinarian for immediate assistance and notify Pfizer Animal Health (1-800-366-5288).

Rimadyl like other drugs of its class is not free from adverse reactions. Owners should be advised of the potential for adverse reactions and be informed of the clinical signs associated with drug intolerance. Adverse reactions may include decreased appetite vomiting diarrhea dark or tarry stools increased water consumption increased urination pale gums due to anemia yellowing of gums skin or white of the eye due to jaundice lethargy incoordination seizure or behavioral changes. Serious adverse reactions associated with this drug class can occur without warning and in rare situations result in death (see Adverse Reactions). Owners should be advised to discontinue Rimadyl therapy and contact their veterinarian immediately if signs of intolerance are observed. The vast majority of patients with drug related adverse reactions have recovered when the signs are recognized the drug is withdrawn and veterinary care if appropriate is initiated. Owners should be advised of the importance of periodic follow up for all dogs during administration of any NSAID.

Keep out of reach of children. Not for human use. Consult a physician in cases of accidental ingestion by humans. For use in dogs only. Do not use in cats.
All dogs should undergo a thorough history and physical examination before initiation of NSAID therapy. Appropriate laboratory tests to establish hematological and serum biochemical baseline data prior to and periodically during administration of any NSAID should be considered. Owners should be advised to observe for signs of potential drug toxicity (see Information for Dog Owners and Adverse Reactions).

During investigational studies for the caplet formulation with twice daily administration of 1 mg/lb no clinically significant adverse reactions were reported. Some clinical signs were observed during field studies (n=297) which were similar for carprofen caplet- and placebo-treated dogs. Incidences of the following were observed in both groups: vomiting (4%) diarrhea (4%) changes in appetite (3%) lethargy (1.4%) behavioral changes (1%) and constipation (0.3%). The product vehicle served as control.
There were no serious adverse events reported during clinical field studies with once daily administration of 2 mg/lb.

Post-Approval Experience:
Although not all adverse reactions are reported the following adverse reactions are based on voluntary post-approval adverse drug experience reporting. The categories of adverse reactions are listed in decreasing order of frequency by body system.
Vomiting diarrhea constipation inappetence melena hematemesis gastrointestinal ulceration gastrointestinal bleeding pancreatitis.
Inappetence vomiting jaundice acute hepatic toxicity hepatic enzyme elevation abnormal liver function test(s) hyperbilirubinemia bilirubinuria hypoalbuminemia. Approximately one-fourth of hepatic reports were in Labrador Retrievers.
Ataxia paresis paralysis seizures vestibular signs disorientation.
Hematuria polyuria polydipsia urinary incontinence urinary tract infection azotemia acute renal failure tubular abnormalities including acute tubular necrosis renal tubular acidosis glucosuria.
Sedation lethargy hyperactivity restlessness aggressiveness.
Immune-mediated hemolytic anemia immune-mediated thrombocytopenia blood loss anemia epistaxis.
Pruritus increased shedding alopecia pyotraumatic moist dermatitis (hot spots) necrotizing panniculitis/vasculitis ventral ecchymosis.
Immunologic or hypersensitivity:
Facial swelling hives erythema.

In rare situations death has been associated with some of the adverse reactions listed above.

Store at controlled room temperature 15°-30°C (59°-86°F).

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Style Item Number Model Number UPC
100mg 60 Count 496167 100 060 496167 100 060
25mg 30 Count 496167 025 030 496167 025 030
75mg 30 Count 496167 075 030 496167 075 030
100mg 30 Count 496167 100 030 496167 100 030
75mg 60 Count 496167 075 060 496167 075 060
25mg 180 Count 496167 025 180 496167 025 180
75mg 180 Count 496167 075 180 496167 075 180
100mg 180 Count 496167 100 180 012PFZ07-100-180
25mg 60 Count 496167 025 060 496167 025 060

Customers Also Bought

Product Image for Novox Chewable Tablets
Novox Chewable Tablets
View Details
Product Image for Rimadyl Chewables
Rimadyl Chewables
View Details
Additional Information:

Please Note: 

This prescription product or therapeutic food is fulfilled by Pet’s Choice Pharmacy, Inc. A licensed pharmacy in all states.  We are only authorized to ship within the United States.  

To order prescription products or therapeutic foods must have an existing, valid veterinarian-client-patient relationship.  Prescription requests are subject to a Drug Utilization Review by a licensed pharmacist for patient safety. By law we can only accept a prescription faxed from your veterinarian or we must have the original prescription.

All prescription products (excluding therapeutic food) are FDA approved, or EPA licensed, to be sold in the US. Prescription products cannot be returned.  

Are we a licensed pharmacy?

The National Association of Boards of Pharmacy (NABP) has approved us as a Safe Site through its .pharmacy verified website program. We are not a licensed pharmacy; however, we are permitted to display pet medications on our site and have prescription orders fulfilled and delivered through our trusted partner, Pet’s Choice Pharmacy, an NABP .pharmacy verified website. This gives you a trusted and affordable alternative to purchase the medications your beloved pets need to maintain quality of life and overall health.

The .Pharmacy Verified program, prior to approval of domain registration, ensures that applicants meet all applicable Program Standards, which address regulatory standards including; to be licensed, registered, or hold appropriate permits where it is headquartered and where its customers reside, to protect patient medical and financial information and to have a clean disciplinary record.

To find out How to Fill your Pets Prescription click on More Information at the top. 

Product Reviews by Customers

Browse Questions and Answers

Sometimes, manufacturers require that products be advertised only at their suggested prices. When we choose to sell these items for less, we display the sale price only in the cart. To see the price, click Add to Cart.
By Continuing to use our site, you consent to our use of cookies to improve your experience. Learn more