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Tri-Heart Plus for Dogs

Prescription Required
Regularly: $23.04
Today's savings: 11%

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up to 25lbs Blue 6ct


In Stock. Usually Ships within 24 hours.

26-50 lbs Green 6ct


In Stock. Usually Ships within 24 hours.

51-100 lbs Brown 6ct


In Stock. Usually Ships within 24 hours.

Shipping weight = 0.75 lb.

All medications are filled by Pet's Choice Pharmacy. More information. Can only be shipped in the United States.
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Product Summary:

Prescription items are NON-RETURNABLE and NON REFUNDABLE

Tri-Heart Plus Chewable Tablets (Ivermectin/Pyrantel)

Tri-Heart Plus is formulated for use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month (30 days) after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense).

Item Specifications:

Tri-Heart® Plus ivermectin/pyrantel chewable tablets should be administered orally at monthly intervals at the recommended minimum dose level of 6mcg of ivermectin per kg (2.72mcg/lb.) and 5mg of pyrantel (as pamoate salt) per kg (2.27mg/lb.) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:
Dogs up to 25 lb.: 1 tablet per month; 68mcg Ivermectin, 57mg Pyrantel (Blue)
Dogs 26-50 lb.: 1 tablet per month; 136mcg Ivermectin, 114mg Pyrantel (Green)
Dogs 51-100 lb.: 1 tablet per month; 272mcg Ivermectin, 227mg Pyrantel (Brown)
Tri-Heart® Plus ivermectin/pyrantel chewable tablets are recommended for dogs 6 weeks of age and older. For dogs over 100 lb., use the appropriate combination of these tablets.

Remove only one chewable tablet at a time from the blister card. Because most dogs find Tri-Heart® Plus chewable tablets palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food or placed in the back of the dog’s mouth for forced swallowing.
Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Tri-Heart® Plus chewable tablets should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Tri-Heart® Plus chewable tablets must be given within a month (30 days) of the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Tri-Heart® Plus chewable tablets and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.
Monthly treatment with Tri-Heart® Plus chewable tablets also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.

Tri-Heart® Plus chewable tablets given orally using the recommended dose and regimen, are effective against the tissue larval stage of D. immitis for a month (30 days) after infection and, as a result, prevent the development of the adult stage. Tri-Heart® Plus chewable tablets are also effective against canine ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense).

In acceptability trials, Tri-Heart® Plus chewable tablets were shown to be a palatable oral dosage form that was consumed at first offering by the majority of dogs.

All dogs should be tested for existing heartworm infection before starting treatment with Tri-Heart® Plus chewable tablets which are not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Tri-Heart® Plus chewable tablets.
While some microfilariae may be killed by the ivermectin in Tri-Heart® Plus chewable tablets at the recommended dose level, Tri-Heart® Plus chewable tablets are not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Store at controlled room temperature of 59-86° F (15-30° C). Protect product from light.

Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.

Adverse Reactions:
In clinical field trials with ivermectin/pyrantel, vomiting or diarrhea within 24 hours of dosing was rarely observed (1.1% of administered doses). The following adverse reactions have been reported following the use of ivermectin at the recommended dose: depression/lethargy, vomiting, anorexia, diarrhea, mydriasis, ataxia, staggering, convulsions and hypersalivation.

Studies with ivermectin indicate that certain dogs of the Collie breed are more sensitive to the effects of ivermectin administered at elevated dose levels (more than 16 times the target use level of 6 mcg/kg) than dogs of other breeds. At elevated doses, sensitive dogs showed adverse reactions which included mydriasis, depression, ataxia, tremors, drooling, paresis, recumbency, excitability, stupor, coma and death. Ivermectin demonstrated no signs of toxicity at 10 times the recommended dose (60 mcg/kg) in sensitive Collies. Results of these trials and bioequivalency studies support the safety of ivermectin products in dogs, including Collies, when used as recommended.
Ivermectin/pyrantel has shown a wide margin of safety at the recommended dose level in dogs, including pregnant or breeding bitches, stud dogs and puppies aged 6 or more weeks. In clinical trials, many commonly used flea collars, dips, shampoos, anthelmintics, antibiotics, vaccines and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease preventive program.
In one trial, where some pups had parvovirus, there was a marginal reduction in efficacy against intestinal nematodes, possibly due to a change in intestinal transit time.

Style Item Number Model Number UPC
51-100 lbs Brown 6ct 406374 LG 012SCH13-272 300611353039
26-50 lbs Green 6ct 406374 MD 012SCH13-136 300611339033
up to 25lbs Blue 6ct 406374 SM 012SCH13-68 300611346048
Additional Information:

Please Note: 

This prescription product or therapeutic food is fulfilled by Pet’s Choice Pharmacy, Inc. A licensed pharmacy in all states, excluding North Carolina. Pet’s Choice is actively working with North Carolina Board of Pharmacy and expect to be licensed to fill prescriptions in 2018. We can only ship to US states. 


To order prescription products or therapeutic foods must have an existing, valid veterinarian-client-patient relationship.  Prescription requests are subject to a Drug Utilization Review by a licensed pharmacist for patient safety.


All prescription products (excluding therapeutic food) are FDA approved, or EPA licensed, to be sold in the US.

Prescription products cannot be returned.  

How do you fill my pet’s prescription order?

We understand how important your pet’s health is to you. That’s why we partnered with Pet’s Choice Pharmacy, a fully accredited Vet-VIPPS national pharmacy. Located in Belleville, Kansas, Pet’s Choice Pharmacy is a trusted partner that is fully licensed to distribute pharmaceutical products in all states, excluding North Carolina. This licensing ensures that they adhere to the proper standards for handling and dispensing pet medications directly to you, at a significant savings.


How does the prescription process happen?

Pet’s Choice Pharmacy will contact your veterinarian directly to obtain the necessary information and approval to dispense the medications ordered. It is helpful to have veterinarian’s name, phone number, and fax number when you place your order so we can speed up contact process with veterinarian. After prescription is verified, your medication will be safely dispensed and shipped directly to you. If you veterinarian does not participate or support online sales, you can mail your script to us directly.

Pet’s Choice Pharmacy  

814 K Street

Belleville, KS 66935 Order #


Are we a licensed pharmacy?

The National Association of Boards of Pharmacy (NABP) has approved us as an Internet Advertiser of prescription drug-related services through its e-Advertiser Approval program. We are not a licensed pharmacy; however, we are permitted to display pet medications on our site and have prescription orders fulfilled and delivered through our trusted partner, Pet’s Choice Pharmacy, a full Vet-VIPPS accredited pharmacy. This gives you a trusted and affordable alternative to purchase the medications your beloved pets need to maintain quality of life and overall health.

If you have any medical questions about your pet, we suggest you speak with your veterinarian before administering any medication.  If you would like to speak with our pharmacy support team about your order, you can contact us directly Monday-Friday 9 am-5 pm EST at (877) 574-2267. If you veterinarian needs to fax your prescription, our fax number is (866) 787-1177.


** By law we can only accept a prescription faxed from your veterinarian or we must have the original prescription**

Product Reviews by Customers

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Browse 2 questions Browse 2 questions and 51 answers
Why did you choose this?
KV Supply Store
It is a good price have used this product for 2 years.
ELENA B on Feb 1, 2019
It is very reasonably priced have been using it for a few years
ELENA B on Nov 7, 2018
It is a good price have used this product for 2 years.
ELENA B on Feb 1, 2019
This is the medication Roxie has been on for years .... We continue on with the same.
Kenneth or Elke J on Nov 10, 2018
It is very reasonably priced have been using it for a few years
ELENA B on Nov 7, 2018
Same as above except she has been on the Tri-heart plus for longer.
Lauralee J on Nov 5, 2018
It's what my vet has been giving my pup and I have had no problems with it.
don g on Nov 2, 2018
Good product at a good price.
BONNIE & TOM R on Oct 3, 2018
My dog takes this easily! Enjoys the taste!
Kristyn T on Sep 19, 2018
I shopped around for the best price and KV supper had the best price hand down. There was other items I purchased that was affordable.
KV Supply is the place to purchase your pets supplies when you're looking for affordable prices.
SHEILA H on Sep 6, 2018
cheaper than heartgard, recommended by AARP as a way to save money
Kimberly T on Aug 22, 2018
I have used tri-heart for many many years, it is cheaper than other heart guard medication and it works just as good. My dogs love them and have had no side affects at all from this medication.
Brenda J on Aug 20, 2018
Easy to use, dogs seem to like it and the price is right. Does the job just like heartgard plus. I have two large dogs and they have to take more than one tablet so it gets expensive and I have to look for alternatives that are the same as the costly brand.
Maria Z on Jul 11, 2018
my vet recommended
Michelle L on Jun 21, 2018
Vet recommended
Linda F on Jun 11, 2018
Good price for a quality product.
BONNIE & TOM R on Jun 5, 2018
vet recommended
erin a on May 29, 2018
Vet recommended
Mayhugh T on May 25, 2018
This product is chemically same as Heart Guard, costs less and therefore best choice for those, like me, with multiple very large (Great Danes) dogs.
Karen P on May 22, 2018
I usually use Heartgard Plus, but this was suggested by KV since they were out of this size and says it has the same dosage and meds as the other.
Maria Z on May 11, 2018
its what I give my dogs for heart worm
CHERYL O on May 7, 2018
CYNTHIA M on Apr 16, 2018
That's not what I ordered!
Cori C on Apr 7, 2018
MATTHEW D on Apr 3, 2018
Same Ingredients as Heartgard Plus but cheaper
DEBBIE H on Apr 1, 2018
I used this last year and both dogs liked the taste of it!
Yvonne B on Mar 16, 2018
Elizabeth B on Mar 6, 2018
It is what my vet prescribed.
Mayhugh T on Mar 3, 2018
works just as well as Heart Guard but cheaper
Brenda J on Feb 26, 2018
My dog's like the taste and gobble them up...
Lisa S on Feb 22, 2018
Prescribed by Vet
Clifford K on Feb 13, 2018
I've used this previously and it seems to be effective and my dogs love the taste.
MAUREEN C on Jan 1, 2018
Vet said heartworm was required
Joe A on Jan 1, 2018
I used before and the price is affordable with more than one dog
Raymond D on Dec 20, 2017
the price was right!
EG A on Dec 5, 2017
KV was out of stock on 12 month Heart Guard.
Steve O. on Dec 4, 2017
Only heartworm pill my Champ (4 lbs) will chew & NOT vomit!
Eileen F on Nov 21, 2017
Low price
Larry C on Nov 14, 2017
FREDERICK C on Nov 12, 2017
Effective product; dogs like them; cost is much lower than previous product used.
Karen P on Nov 6, 2017
very reasonable it works
ELENA B on Oct 20, 2017
I was about to buy Heartgard Plus when I saw that Tri-Heart Plus was cheaper, so I thought we'd try it out.
Heather S on Oct 18, 2017
Better price then other products and my dog likes them.
LINDA M on Oct 8, 2017
My vet whom I trust implicitly recommended them.
Stacy S on Aug 27, 2017
my dogs have always used it with no side effects
THOMAS L on Aug 27, 2017
trying this cause iverhart plus is out & it's similar price point for heart meds.
GINGER E on Aug 19, 2017
Dogs currently on it, tolerated, reasonable priced
JEANINE W on Aug 17, 2017
Because another brand I normally purchase is out of stock.
DEAN B on Aug 10, 2017
RICHARD S on Aug 8, 2017
cost effective
Robyn D on Aug 6, 2017
The price was more affordable than the name brand. I have used it before, and my dog likes it.
Karen V on Aug 3, 2017
Excellent heartworm+ preventative. Have used it for several years.
LAURIE M on Jul 25, 2017
This is the medication Roxie has been on for years .... We continue on with the same.
Kenneth or Elke J on Nov 10, 2018
Same as above except she has been on the Tri-heart plus for longer.
Lauralee J on Nov 5, 2018
How many pills?
Brad H on Jul 26, 2017
BEST ANSWER: Hi there,

These come in a 6-count box.