TOLL FREE: 1.800.423.8211

Trifexis Chewable Tablets for Dogs

Prescription Required
From $17.49


Sometimes, manufacturers require that products be advertised only at their suggested prices. When we choose to sell these items for less, we display the sale price only in the cart. To see the price, click Add to Cart.

Select your product options above to view the stock and delivery information.

Questions or Feedback? Contact us now.

All medications are filled by Pet's Choice Pharmacy. More information. Can only be shipped in the United States.
Buy More and Save!*
Save item Item saved

Product Summary:

Prescription items are NON-RETURNABLE and NON REFUNDABLE

Trifexis® Chewable Tablets for Dogs

Trifexis is a monthly, chewable tablet for dogs that kills fleas, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis combines two trusted active ingredients to provide protection for your dog against these dangerous parasites. Trifexis starts working within 30 minutes from administration of this medicine to kill fleas and has been proven to kill all biting fleas within four hours. Trifexis also kills flea eggs before they can mature, which puts an end to the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms. Trifexis comes in a tasty beef-flavored tablet (made from pork liver and hydrolyzed soy) for ease of administration to your dog.

Item Specifications:

Trifexis is used to prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections.

For Use:
Dogs (at least 8 weeks of age and weighing at least 5 lb.)

Strength/Size: X-small (Pink) for dogs 5-10 lb.
Small (Orange) for dogs 10.1-20 lb.
Medium (Green) for dogs 20.1-40 lb.
Large (Blue_ for dogs 40.1-60 lb.
Xlarge (Brown) for dogs 60.1-120 lb.

Active Ingredient(s):
Spinosad, milbemycin oxime

Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. This medication is generally well tolerated with other commonly prescribed medications. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together. Allergic reactions to medications may occur. Be sure to inform your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.

Side Effects:
Side effects may include nausea, vomiting, diarrhea, loss of appetite, decreased activity, itching, redness and inflammation of the skin. If you notice anything unusual, contact your veterinarian.

Trifexis should be given orally as directed veterinarian. Give Trifexis with food for maximum effectiveness.

Style Item Number Model Number UPC
40-60lbs 1 Month 497063 LG 1CT 012ELC-40-1-60-1
40-60lbs 6 Month 497063 LG 6CT 012ELC-40-1-60 309864335069
20-40lbs 1 Month 497063 MD 1CT 012ELC-20-1-40-1
20-40lbs 6 Month 497063 MD 6CT 012ELC-20-1-40 309864334062
10-20lbs 1 Month 497063 SM 1CT 012ELC-10-1-20-1
10-20lbs 6 Month 497063 SM 6CT 012ELC-10-1-20 309864333065
60-120lbs 1 Month 497063 XL 1CT 012ELC-60-1-120-1
60-120lbs 6 Month 497063 XL 6CT 012ELC-60-1-120 727804326777
5-10lbs 1 Month 497063 XS 1CT 012ELC-5-10-1
5-10lbs 6 Month 497063 XS 6CT 012ELC-5-10 727804322731
Additional Information:

Please Note: 

This prescription product or therapeutic food is fulfilled by Pet’s Choice Pharmacy, Inc. A licensed pharmacy in all states, excluding North Carolina. Pet’s Choice is working with North Carolina Board of Pharmacy to be licensed to fill prescriptions in the future. We can only ship to US states. 

To order prescription products or therapeutic foods must have an existing, valid veterinarian-client-patient relationship.  Prescription requests are subject to a Drug Utilization Review by a licensed pharmacist for patient safety.

All prescription products (excluding therapeutic food) are FDA approved, or EPA licensed, to be sold in the US. Prescription products cannot be returned.  


How do you fill my pet’s prescription order?

We understand how important your pet’s health is to you. That’s why we partnered with Pet’s Choice Pharmacy, a fully accredited Vet-VIPPS national pharmacy. Located in Belleville, Kansas, Pet’s Choice Pharmacy is a trusted partner that is fully licensed to distribute pharmaceutical products in all states, excluding North Carolina. This licensing ensures that they adhere to the proper standards for handling and dispensing pet medications directly to you, at a significant savings.


How does the prescription process happen?

Pet’s Choice Pharmacy will contact your veterinarian directly to obtain the necessary information and approval to dispense the medications ordered. It is helpful to have veterinarian’s name, phone number, and fax number when you place your order so we can speed up contact process with veterinarian. After prescription is verified, your medication will be safely dispensed and shipped directly to you. If you veterinarian does not participate or support online sales, you can mail your script to us directly.


Pet’s Choice Pharmacy  

814 K Street

Belleville, KS 66935 Order #


Are we a licensed pharmacy?

The National Association of Boards of Pharmacy (NABP) has approved us as an Internet Advertiser of prescription drug-related services through its e-Advertiser Approval program. We are not a licensed pharmacy; however, we are permitted to display pet medications on our site and have prescription orders fulfilled and delivered through our trusted partner, Pet’s Choice Pharmacy, a full Vet-VIPPS accredited pharmacy. This gives you a trusted and affordable alternative to purchase the medications your beloved pets need to maintain quality of life and overall health.


If you have any medical questions about your pet, we suggest you speak with your veterinarian before administering any medication.  If you would like to speak with our pharmacy support team about your order, you can contact us directly Monday-Friday 9 am-5 pm EST at (877) 574-2267. If you veterinarian needs to fax your prescription, our fax number is (866) 787-1177.


** By law we can only accept a prescription faxed from your veterinarian or we must have the original prescription**


Product Reviews by Customers

Start typing your question and we'll check if it was already asked and answered. Learn More
Browse 17 questions Browse 17 questions and 77 answers
Why did you choose this?
KV Supply Store
dogs do best with this heartworm treatment
shanale s on May 21, 2019
This is the only med that has worked for my dog in preventing heartworms AND killing off the ticks and fleas.
JANET S on May 7, 2019
dogs do best with this heartworm treatment
shanale s on May 21, 2019
Vets Recommendation
Alfred K on May 17, 2019
This is the only med that has worked for my dog in preventing heartworms AND killing off the ticks and fleas.
JANET S on May 7, 2019
Saved $38 on my dog's Trifexis.
Tammy A on Apr 24, 2019
Veterinarian required.
Barbara B on Apr 17, 2019
Great price for the 6 month supply!
Rachel W on Apr 15, 2019
doctor prescribed
Sue R on Apr 11, 2019
Veterinarian recommended
BARBARA S on Apr 6, 2019
it works for our needs
Donna O on Mar 25, 2019
Vet recommended
Jeff B on Mar 13, 2019
Because the dogs will take it more easily and we are familiar with the product.
Michele B on Mar 6, 2019
This work very well for preventing Heartworm and it is a great preventable medication for fleas. I have not seen fleas in years and my dog has never had any problems with this medication.
Deborah N on Feb 10, 2019
It helps my dogs from getting sick and fleas all in one....
Debbie G on Feb 5, 2019
she's been on it for awhile..avoids the flea topical mess & does double duty BUT she hates t...I have to pulverize it and disguise it in her food
Larraine B on Feb 1, 2019
It's what the vet put him on. No need to change even though he hates them and we have to hold him and force him to swallow it.
CHERYL M on Jan 24, 2019
This is just continuation of therapy for our baby.
Dee A on Jan 14, 2019
cheaper price than petsmart
Marisa M on Dec 31, 2018
Doctor's prescription. Cheaper than through doctor;s office.
David R on Dec 10, 2018
Good price
Ryan H on Dec 4, 2018
I'll save 120.00 a year purchasing from KV Supply.
Sherry S on Dec 3, 2018
I saved 75.00 on a 6 month supply of my dogs meds.
Sherry S on Nov 28, 2018
This is fast, cheap and easy.
Rachel W on Nov 26, 2018
Recommended by my dad for cost and for effectiveness. My westie eats it no problem but my miniature schnauzer plays with it before nibbling on it.
Steven B on Nov 13, 2018
My dogs have been on this medicine for a long time, I like that it covers everything.
Shelly S on Nov 7, 2018
used it before
FREDA M on Nov 5, 2018
Helpful due to it being a combination of heartworm prevention & killing of fleas.
CHRIS D on Oct 18, 2018
Good product and my dog doesn't mind eating them (with some peanut butter)
YASMIN B on Oct 15, 2018
Vet recommended... helps keep my fur baby's heart healthy and free of ticks and fleas.
Karen B on Sep 14, 2018
Prescribed by vet
Philip M on Sep 14, 2018
Recommended by my vet and keeps my dog and home free of fleas plus no heartworms too!
SUZANNE B on Sep 2, 2018
AIO maintance medication. Great to assure that your furry kid is covered AND that the meds are completely absorbed (unlike with topicals).
Sabre S on Aug 27, 2018
Flea & heartworm meds all in one.
Chi L on Aug 21, 2018
Vet recommended. Our dogs have been on it since they were born. Our previous Boxer took them as well.
Eric C on Aug 8, 2018
recommended by vet
Carolyn W on Aug 8, 2018
LOve that it helps them with there heart and worms and fleas all at once....
Debbie G on Aug 7, 2018
includes flea prevention with heart worm prevention
WALT M on Jul 28, 2018
Works well and my vet recommended this product.
Kim W on Jul 8, 2018
$50.00 cheaper that Vet's office!
Bo W on Jul 4, 2018
The only thing that works for my dog!
Kathy T on Jul 3, 2018
Excellent product that kills flees AND prevents heartworms.
Bruce L on Jul 1, 2018
Trifexis works well for my great dane.
Christina T on Jun 28, 2018
Good price
JONATHAN C on Jun 23, 2018
Vet recommended Trifexis
JOANN C on Jun 20, 2018
Because it covers not only heart worm but also flees
Shelly H on Jun 20, 2018
I only have to give one pill and it covers Heart worms, fleas, and intestinal worms. saves money, that way
NORMA C on Jun 20, 2018
I have three dogs, with one allergic to topical flea/tick applications. Even though Trifexis upsets their tummies the first day, it seems to be the best alternative to topical medications. The Trifexis really does keep the fleas and ticks at bay.
Dawn D on Jun 19, 2018
savings because no need to buy two different pills for fleas and heart worms, and also it works! Its been Ranch Dog Approved!
Dogtown Ranch A on Jun 17, 2018
Angela C on Jun 15, 2018
Best price
David R on Jun 13, 2018
Best price I could find!
Brenda T on Jun 8, 2018
Vets Recommendation
Alfred K on May 17, 2019
Saved $38 on my dog's Trifexis.
Tammy A on Apr 24, 2019
don't you need my vet's prescription?
A shopper on Feb 19, 2019
BEST ANSWER: Yes, you need an Rx from your vet. When you place the order there should be a field to enter your vet's name so KV can contact him/her for them to upload the Rx.
Does this protect my dog heart?
A shopper on Nov 8, 2018
BEST ANSWER: Yes. It protects against fleas, heart worms, and some intestinal parasites. It does not protect against ticks, though.
How many chewable tablets are there in the box?
Justin G on Jun 3, 2018
BEST ANSWER: It depends on what size box you buy. There is 1 ( one ) tablet per month. I buy a 6 month supply so there are 6 tablets in the box. If you order a 1 (one ) month supply, you would get 1 (one) tablet.
Do you contact the vet for the okay to fill?
Kathy on Aug 1, 2017
BEST ANSWER: Hi Mary! Yes, once the order is placed, we reach out to the Vet to obtain the prescription for your pet.
Can you please give me the address to mail the veterinarian prescription to?
Lin N on Jun 13, 2018
BEST ANSWER: Hi there,
If you wish to mail your prescription to our pharmacy, the address is below.
Pet's Choice Pharmacy
814 K Street
Belleville, KS 66935
Does this product kill ticks? Up to 10 lbs
A shopper on Jul 17, 2018
BEST ANSWER: Item does not kill ticks. It kills fleas, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections.
My dog weights less than 2 lbs. can I still use this??
A shopper on Jun 3, 2018
BEST ANSWER: Hi there,

This is something you would want to discuss with your Veterinarian.
does Trifexis kill ticks?
A shopper on May 2, 2018
BEST ANSWER: No, trifexis is for roundworms ect. For ticks there is bravecto and Nexgard, which both require a prescription from a vet.
do you have 12 month supply trifexis for 10-20 pound?
e h on Jan 9, 2018
BEST ANSWER: At this time we only sell them by the 6 month.
Are you licensed in North Carolina yet?
Jennifer R on Oct 2, 2017
BEST ANSWER: I apologize, not yet.
i was referred to you from another website and it said you offered a 12 ct (2 6-packs i guess) but i do not see an option to purchase 2? is this possible or can i only get 1 6-pack?
jason s on Aug 30, 2017
BEST ANSWER: Hi Jason! Change the number in the quantity box from 1 to 2 and then click 'ADD TO CART'.
Is this for heart worms too?
Melissa E on Aug 16, 2017
BEST ANSWER: Benefits:
Trifexis is used to prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections.
Does a vet have to order trifexis for you?
Lakeisha B on Aug 15, 2017
BEST ANSWER: Hi Lakeisha! The vet does not have to order this for you but they do need to give you a prescription.
Can I half trifexis ?
A shopper on Aug 5, 2017
BEST ANSWER: Hi there,

This would be something that would have to be discussed with your Veterinarian. Good luck!
Is this the real brand? Why is it so cheap?
Sammy on Aug 3, 2017
BEST ANSWER: This is the real Trifexis manufactured by Elanco.
Do you accept manufacturers l coupons?do you accept manufacturers coupons?
Judy M on Jul 22, 2017
BEST ANSWER: Hi there,

At this time we do not accept manufacturer coupons.