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Trifexis Chewable Tablets for Dogs

Prescription Required
From $18.49


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All medications are filled by Pet's Choice Pharmacy. More information. Can only be shipped in the United States.
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Product Summary:

Trifexis® Chewable Tablets for Dogs

Trifexis is a monthly, chewable tablet for dogs that kills fleas, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Trifexis combines two trusted active ingredients to provide protection for your dog against these dangerous parasites. Trifexis starts working within 30 minutes from administration of this medicine to kill fleas and has been proven to kill all biting fleas within four hours. Trifexis also kills flea eggs before they can mature, which puts an end to the flea life cycle. Trifexis prevents heartworm disease by killing microfilariae and larvae from maturing into adult heartworms. Trifexis comes in a tasty beef-flavored tablet (made from pork liver and hydrolyzed soy) for ease of administration to your dog.

Item Specifications:

Trifexis is used to prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections.

For Use:
Dogs (at least 8 weeks of age and weighing at least 5 lb.)

Strength/Size: X-small (Pink) for dogs 5-10 lb.
Small (Orange) for dogs 10.1-20 lb.
Medium (Green) for dogs 20.1-40 lb.
Large (Blue_ for dogs 40.1-60 lb.
Xlarge (Brown) for dogs 60.1-120 lb.

Active Ingredient(s):
Spinosad, milbemycin oxime

Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Make sure to tell your veterinarian what other medication you are giving to your pet. Quite often your veterinarian may prescribe two different medications, even if a drug interaction may occur. In this case, your veterinarian may vary the dose and/or monitor your pet more closely. This medication is generally well tolerated with other commonly prescribed medications. Contact your veterinarian if your pet experiences any unusual reactions when different medications are given together. Allergic reactions to medications may occur. Be sure to inform your veterinarian if your pet has any known drug sensitivities or allergies. If your pet displays symptoms of an allergic reaction, call your veterinarian immediately or go to a veterinary emergency clinic. Symptoms may include but are not limited to: swollen lips, tongue, face, airways; difficulty breathing; agitation; profuse salivation; vomiting; widespread hives and itching.

Side Effects:
Side effects may include nausea, vomiting, diarrhea, loss of appetite, decreased activity, itching, redness and inflammation of the skin. If you notice anything unusual, contact your veterinarian.

Trifexis should be given orally as directed veterinarian. Give Trifexis with food for maximum effectiveness.

Style Item Number Model Number UPC
40-60lbs 1 Month 497063 LG 1CT 012ELC-40-1-60-1
40-60lbs 6 Month 497063 LG 6CT 012ELC-40-1-60 309864335069
20-40lbs 1 Month 497063 MD 1CT 012ELC-20-1-40-1
20-40lbs 6 Month 497063 MD 6CT 012ELC-20-1-40 309864334062
10-20lbs 1 Month 497063 SM 1CT 012ELC-10-1-20-1
10-20lbs 6 Month 497063 SM 6CT 012ELC-10-1-20 309864333065
60-120lbs 1 Month 497063 XL 1CT 012ELC-60-1-120-1
60-120lbs 6 Month 497063 XL 6CT 012ELC-60-1-120 727804326777
5-10lbs 1 Month 497063 XS 1CT 012ELC-5-10-1
5-10lbs 6 Month 497063 XS 6CT 012ELC-5-10 727804322731
Additional Information:

Please Note: 

This prescription product or therapeutic food is fulfilled by Pet’s Choice Pharmacy, Inc. A licensed pharmacy in all states, excluding North Carolina. Pet’s Choice is actively working with North Carolina Board of Pharmacy and expect to be licensed to fill prescriptions in 2018. We can only ship to US states. 


To order prescription products or therapeutic foods must have an existing, valid veterinarian-client-patient relationship.  Prescription requests are subject to a Drug Utilization Review by a licensed pharmacist for patient safety.


All prescription products (excluding therapeutic food) are FDA approved, or EPA licensed, to be sold in the US.

Prescription products cannot be returned.  

How do you fill my pet’s prescription order?

We understand how important your pet’s health is to you. That’s why we partnered with Pet’s Choice Pharmacy, a fully accredited Vet-VIPPS national pharmacy. Located in Belleville, Kansas, Pet’s Choice Pharmacy is a trusted partner that is fully licensed to distribute pharmaceutical products in all states, excluding North Carolina. This licensing ensures that they adhere to the proper standards for handling and dispensing pet medications directly to you, at a significant savings.


How does the prescription process happen?

Pet’s Choice Pharmacy will contact your veterinarian directly to obtain the necessary information and approval to dispense the medications ordered. It is helpful to have veterinarian’s name, phone number, and fax number when you place your order so we can speed up contact process with veterinarian. After prescription is verified, your medication will be safely dispensed and shipped directly to you. If you veterinarian does not participate or support online sales, you can mail your script to us directly.

Pet’s Choice Pharmacy  

814 K Street

Belleville, KS 66935 Order #


Are we a licensed pharmacy?

The National Association of Boards of Pharmacy (NABP) has approved us as an Internet Advertiser of prescription drug-related services through its e-Advertiser Approval program. We are not a licensed pharmacy; however, we are permitted to display pet medications on our site and have prescription orders fulfilled and delivered through our trusted partner, Pet’s Choice Pharmacy, a full Vet-VIPPS accredited pharmacy. This gives you a trusted and affordable alternative to purchase the medications your beloved pets need to maintain quality of life and overall health.

If you have any medical questions about your pet, we suggest you speak with your veterinarian before administering any medication.  If you would like to speak with our pharmacy support team about your order, you can contact us directly Monday-Friday 9 am-5 pm EST at (877) 574-2267. If you veterinarian needs to fax your prescription, our fax number is (866) 787-1177.


** By law we can only accept a prescription faxed from your veterinarian or we must have the original prescription**

Product Reviews by Customers

4.3 / 5.0
18 Reviews
5 Stars
4 Stars
3 Stars
2 Stars
1 Star
3.9 / 5
Like the ability to purchase one tablet at a time.
October 7, 2018
1 month ago
5 / 5
Very satisfied.
Absolutely love this product. Wish I found it sooner !
September 12, 2018
3 months ago
1 / 5
Great deal!
Great deal!
August 22, 2018
6 months ago
Waiting for it to arrive...
I have not yet received the product!
July 29, 2018
3 months ago
One simple step
I’ve given this to my dogs for years, and highly recommend it.
July 10, 2018
3 months ago
1 / 5
Still waiting.
We have been waiting over two weeks and still have not received our order. I have called and was told we would be called back and have not heard a thing. Very disappointed in the customer service.
June 20, 2018
4 months ago
Response from KV Supply
Pearlie, May i have the order number to assist you?
June 21, 2018
Glendaly H
5 / 5
Satisfied first time customer...
I’ve used trifexis for years for my yorkie. I’ve never had any issues with this medication. I typically purchase it from 1-800-pet-meds but KV Supply offered it for a cheaper price. This was my first time ordering from KV Supply but I suspect it won’t be my last. My order arrived quickly without any incidents. It was a pleasurable experience. I would recommend KV Supply. Thank you.
June 11, 2018
4 months ago
5 / 5
My Dog ate it no Problem
KV had the best online price I could find.
June 1, 2018
5 months ago
Very Satisfied
Ordered through KV Supply at the recommendation of several responsible dog breeders who include friends, colleagues and the breeder of my beloved Lhasa Apsos. I'm very pleased with the pricing and delivery turnaround from KV and will definitely order from them again.
May 11, 2018
6 months ago
same product you would rec'v from a vet but saving a lot of money
April 23, 2018
6 months ago
Start typing your question and we'll check if it was already asked and answered. Learn More
Browse 15 questions Browse 15 questions and 68 answers
Why did you choose this?
KV Supply Store
Helpful due to it being a combination of heartworm prevention & killing of fleas.
CHRIS D on Oct 18, 2018
Vet recommended... helps keep my fur baby's heart healthy and free of ticks and fleas.
Karen B on Sep 14, 2018
Helpful due to it being a combination of heartworm prevention & killing of fleas.
CHRIS D on Oct 18, 2018
Good product and my dog doesn't mind eating them (with some peanut butter)
YASMIN B on Oct 15, 2018
Vet recommended... helps keep my fur baby's heart healthy and free of ticks and fleas.
Karen B on Sep 14, 2018
Prescribed by vet
Philip M on Sep 14, 2018
Recommended by my vet and keeps my dog and home free of fleas plus no heartworms too!
SUZANNE B on Sep 2, 2018
AIO maintance medication. Great to assure that your furry kid is covered AND that the meds are completely absorbed (unlike with topicals).
Sabre S on Aug 27, 2018
Flea & heartworm meds all in one.
Chi L on Aug 21, 2018
Vet recommended. Our dogs have been on it since they were born. Our previous Boxer took them as well.
Eric C on Aug 8, 2018
recommended by vet
Carolyn W on Aug 8, 2018
LOve that it helps them with there heart and worms and fleas all at once....
Debbie G on Aug 7, 2018
includes flea prevention with heart worm prevention
WALT M on Jul 28, 2018
Works well and my vet recommended this product.
Kim W on Jul 8, 2018
$50.00 cheaper that Vet's office!
Bo W on Jul 4, 2018
The only thing that works for my dog!
Kathy T on Jul 3, 2018
Excellent product that kills flees AND prevents heartworms.
Bruce L on Jul 1, 2018
Trifexis works well for my great dane.
Christina T on Jun 28, 2018
Good price
JONATHAN C on Jun 23, 2018
Vet recommended Trifexis
JOANN C on Jun 20, 2018
Because it covers not only heart worm but also flees
Shelly H on Jun 20, 2018
I only have to give one pill and it covers Heart worms, fleas, and intestinal worms. saves money, that way
NORMA C on Jun 20, 2018
I have three dogs, with one allergic to topical flea/tick applications. Even though Trifexis upsets their tummies the first day, it seems to be the best alternative to topical medications. The Trifexis really does keep the fleas and ticks at bay.
Dawn D on Jun 19, 2018
savings because no need to buy two different pills for fleas and heart worms, and also it works! Its been Ranch Dog Approved!
Dogtown Ranch A on Jun 17, 2018
Angela C on Jun 15, 2018
Best price
David R on Jun 13, 2018
Best price I could find!
Brenda T on Jun 8, 2018
Simply put.... IT WORKS
Bryan B on Jun 7, 2018
Works better than ordering 3 different medications
Cheryl K on Jun 2, 2018
Best flea treatment we have found,.
Janine C on Jun 1, 2018
Recommended by vet
Philip M on Jun 1, 2018
cost and reliable delivery
david w on Jun 1, 2018
Recommended by my vet to be the best choice for my pet
Donald A on May 31, 2018
GARY G on May 25, 2018
Once a month to take care of fleas,ticks and heartworm prevention, hookworm, roundworm and whipworm protection. Very convenient and it truly works. My dog tolerates it well.
Susan A on May 23, 2018
Works the best for flea protection for my pet dog!
Jeffrey W on May 20, 2018
they work great on my them
Debbie G on May 19, 2018
Effectively controls parasites in my dogs. Have not experienced any problems using this product.
Melissa E on May 17, 2018
It is more convenient and less expensive to give my dogs heartworm and flea medicine as one.
Mary Ellen S on May 15, 2018
This medication was recommended by the staff at our veterinarian's office for it's dual treatment of heartworm and flea protection. We have never tried it before but we hope for the best. If it works, it could save us about 100 dollars a year in flea control.
Patricia H on May 14, 2018
because vet recommended it.
yong t on May 11, 2018
Vet Recommendation and one pill kills heartworms, fleas and ticks!
Terri K on May 9, 2018
discounted price
Raymond Eric P on May 7, 2018
Most effective
Olivia R on May 4, 2018
came highly recommended by my vet and dog trainer.
Kay H on May 1, 2018
Vet's recommended product.
Robert L on Apr 30, 2018
easier than 2 pills, and cheaper
Pam S on Apr 28, 2018
I believe this is one of the best Heart Worm medicines on the market.
Summer D on Apr 25, 2018
They work! I have had my Pit Bull on Trifexis since he was big enough to take it. I have never had a single issue with it. He's completely worm free. Also, fleas do not stand a chance! If he does get one on him seems like they are dead within minutes! I also noticed that the flea issue we had in our yard before is now non-existent. Highly recommend,
Katelyn B on Apr 24, 2018
These options work best for our big babies
LEIGH B on Apr 11, 2018
It works!!!!
William R on Apr 9, 2018
are pet has been taking this RX from the time she was allowed to start taking this med as a puppy now she is 14-1/2 years old she never had a drug reaction from this and it works.. she takes it 6 month per year from May to October.. we live in the mid west
MARK S on Apr 9, 2018
Good product and my dog doesn't mind eating them (with some peanut butter)
YASMIN B on Oct 15, 2018
Prescribed by vet
Philip M on Sep 14, 2018
How many chewable tablets are there in the box?
Justin G on Jun 3, 2018
BEST ANSWER: It depends on what size box you buy. There is 1 ( one ) tablet per month. I buy a 6 month supply so there are 6 tablets in the box. If you order a 1 (one ) month supply, you would get 1 (one) tablet.
Can you please give me the address to mail the veterinarian prescription to?
Lin N on Jun 13, 2018
BEST ANSWER: Hi there,
If you wish to mail your prescription to our pharmacy, the address is below.
Pet's Choice Pharmacy
814 K Street
Belleville, KS 66935
Do you contact the vet for the okay to fill?
Kathy on Aug 1, 2017
BEST ANSWER: Hi Mary! Yes, once the order is placed, we reach out to the Vet to obtain the prescription for your pet.
Does this product kill ticks? Up to 10 lbs
A shopper on Jul 17, 2018
BEST ANSWER: Item does not kill ticks. It kills fleas, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections.
My dog weights less than 2 lbs. can I still use this??
A shopper on Jun 3, 2018
BEST ANSWER: Hi there,

This is something you would want to discuss with your Veterinarian.
does Trifexis kill ticks?
A shopper on May 2, 2018
BEST ANSWER: No, trifexis is for roundworms ect. For ticks there is bravecto and Nexgard, which both require a prescription from a vet.
do you have 12 month supply trifexis for 10-20 pound?
e h on Jan 9, 2018
BEST ANSWER: At this time we only sell them by the 6 month.
Are you licensed in North Carolina yet?
Jennifer R on Oct 2, 2017
BEST ANSWER: I apologize, not yet.
i was referred to you from another website and it said you offered a 12 ct (2 6-packs i guess) but i do not see an option to purchase 2? is this possible or can i only get 1 6-pack?
jason s on Aug 30, 2017
BEST ANSWER: Hi Jason! Change the number in the quantity box from 1 to 2 and then click 'ADD TO CART'.
Is this for heart worms too?
Melissa E on Aug 16, 2017
BEST ANSWER: Benefits:
Trifexis is used to prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections.
Does a vet have to order trifexis for you?
Lakeisha B on Aug 15, 2017
BEST ANSWER: Hi Lakeisha! The vet does not have to order this for you but they do need to give you a prescription.
Can I half trifexis ?
A shopper on Aug 5, 2017
BEST ANSWER: Hi there,

This would be something that would have to be discussed with your Veterinarian. Good luck!
Is this the real brand? Why is it so cheap?
Sammy on Aug 3, 2017
BEST ANSWER: This is the real Trifexis manufactured by Elanco.
Do you accept manufacturers l coupons?do you accept manufacturers coupons?
Judy M on Jul 22, 2017
BEST ANSWER: Hi there,

At this time we do not accept manufacturer coupons.